ACAT1 (K266) polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS3796
Background:
ACAT-1 (acetyl-Coenzyme A acetyltransferase 1) is a mitochondrial enzyme involved in the formation and degradation of ketone bodies and is necessary for the proper metabolic processing of isoleucine. Rare defects in the gene encoding ACAT-1 lead to β-ketothiolase deficiency, which is characterized by ketoacidotic attacks. ACAT-2 (acetyl-Coenzyme A acetyltransferase 2) is considered a cytosolic protein and is crucial for cholesterol synthesis. Specifically, both Acetoacetyl-CoA specific thiolases, ACAT-1 and ACAT-2 catalyze the formation of acetoacetyl-CoA from two acetyl-CoA molecules. These enzymes are also capable of the reverse reaction, the cleavage of acetoacetyl-CoA into two acetyl-CoA molecules.
Alternative Name:
Acetyl-CoA acetyltransferase, mitochondrial, Acetoacetyl-CoA thiolase, ACAT1, ACAT, MAT, ACAT-1
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200
Specificity: ACAT1 (K266) polyclonal antibody detects endogenous levels of ACAT1 protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 235-286 of Human ACAT1.
MW: ~ 45 kDa
Swis Prot.: P24752
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
ACAT-1 (acetyl-Coenzyme A acetyltransferase 1) is a mitochondrial enzyme involved in the formation and degradation of ketone bodies and is necessary for the proper metabolic processing of isoleucine. Rare defects in the gene encoding ACAT-1 lead to β-ketothiolase deficiency, which is characterized by ketoacidotic attacks. ACAT-2 (acetyl-Coenzyme A acetyltransferase 2) is considered a cytosolic protein and is crucial for cholesterol synthesis. Specifically, both Acetoacetyl-CoA specific thiolases, ACAT-1 and ACAT-2 catalyze the formation of acetoacetyl-CoA from two acetyl-CoA molecules. These enzymes are also capable of the reverse reaction, the cleavage of acetoacetyl-CoA into two acetyl-CoA molecules.
Alternative Name:
Acetyl-CoA acetyltransferase, mitochondrial, Acetoacetyl-CoA thiolase, ACAT1, ACAT, MAT, ACAT-1
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200
Specificity: ACAT1 (K266) polyclonal antibody detects endogenous levels of ACAT1 protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 235-286 of Human ACAT1.
MW: ~ 45 kDa
Swis Prot.: P24752
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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