CD156a (ADAM8) polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS60722
Background:
ADAM (a disintegrin and metalloprotease) proteins are a family of over 30 membrane-anchored, glycosylated, Zn2+ dependent proteases that are involved in cell-cell, cell-matrix interface related processes including fertilization, muscle fusion, secretion of TNFå and modulation of the neurogenic function of Notch and Delta. ADAM proteins possess a signal-domain, a pro-domain, a metalloprotease domain, a disintegrin domain (Integrin ligand), a cysteine-rich region, an epidermal growth factor-like domain, a transmembrane domain and a cytoplasmic tail. ADAMs are expressed in brain, testis, epididymis, ovary, breast, placenta, liver, heart, lung, bone and muscle, and catalyze proteolysis, adhesion, fusion, and intracellular signaling. ADAM 8 (CD156, MS2) is a 824 amino acid protein that contains a 16 amino acid signal peptide, a 637 amino acid extracellular region, a 25 amino acid transmembrane region and a 146 amino acid cytoplasmic region which possesses a cytoplasmic consensus Src homology 3 (SH3)-binding domain.
Alternative Name:
Disintegrin and metalloproteinase domain-containing protein 8 , ADAM 8, Cell surface antigen MS2, CD156a, ADAM8, MS2
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200
Specificity: ADAM8 polyclonal antibody detects endogenous levels of ADAM8 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human ADAM8
MW: ~ 89 kDa
Swis Prot.: P78325
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
ADAM (a disintegrin and metalloprotease) proteins are a family of over 30 membrane-anchored, glycosylated, Zn2+ dependent proteases that are involved in cell-cell, cell-matrix interface related processes including fertilization, muscle fusion, secretion of TNFå and modulation of the neurogenic function of Notch and Delta. ADAM proteins possess a signal-domain, a pro-domain, a metalloprotease domain, a disintegrin domain (Integrin ligand), a cysteine-rich region, an epidermal growth factor-like domain, a transmembrane domain and a cytoplasmic tail. ADAMs are expressed in brain, testis, epididymis, ovary, breast, placenta, liver, heart, lung, bone and muscle, and catalyze proteolysis, adhesion, fusion, and intracellular signaling. ADAM 8 (CD156, MS2) is a 824 amino acid protein that contains a 16 amino acid signal peptide, a 637 amino acid extracellular region, a 25 amino acid transmembrane region and a 146 amino acid cytoplasmic region which possesses a cytoplasmic consensus Src homology 3 (SH3)-binding domain.
Alternative Name:
Disintegrin and metalloproteinase domain-containing protein 8 , ADAM 8, Cell surface antigen MS2, CD156a, ADAM8, MS2
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200
Specificity: ADAM8 polyclonal antibody detects endogenous levels of ADAM8 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human ADAM8
MW: ~ 89 kDa
Swis Prot.: P78325
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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