ALKBH3 polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS7871
Background:
ALKBH3 (alkB, alkylation repair homolog 3), also known as ABH3, PCA1 (prostate cancer antigen 1), DEPC1 or DEPC-1, is a 286 amino acid member of the AlkB family of proteins and functions as a dioxygenase with a preference for RNA and single stranded DNA substrates. ALKBH3 is one of many homologs of the Escherichia coli protein, AlkB. ALKBH3 is expressed in a wide variety of tissues and localizes to the cytoplasm and the nucleus. It associates with iron and 2-oxoglutarate, coupling the oxidation of substrates to the conversion of 2-oxoglutarate into succinate and CO2. Via oxidative demethylation, ALKBH3 repairs 1-methyladenine and 3-methylcytosine lesions in alkylated DNA and RNA. Its activity is stimulated by ascorbate. Two isoforms exist for ALKBH3 due to alternative splicing of the gene.
Alternative Name:
ABH3, AlkB homolog 3, alkB, alkylation repair homolog 3 (E. coli), ALKB3_HUMAN, ALKBH3, Alkylated DNA repair protein alkB homolog 3, alkylation repair homolog 3, Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3, DEPC 1, DEPC-1, DEPC1, EC 1.14.11., FLJ43614, mABH3, MGC118790, MGC118792, MGC118793, MGC134125, PCA1, Prostate cancer antigen 1, prostate cancer antigen-1, RP23-375N21.4,
Application Dilution: WB: 1:500~1:2000
Specificity: ALKBH3 polyclonal antibody detects endogenous levels of ALKBH3 protein.
Immunogen:
Recombinant full length Human ALKBH3.
MW: ~ 33 kDa
Swis Prot.: Q96Q83
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
ALKBH3 (alkB, alkylation repair homolog 3), also known as ABH3, PCA1 (prostate cancer antigen 1), DEPC1 or DEPC-1, is a 286 amino acid member of the AlkB family of proteins and functions as a dioxygenase with a preference for RNA and single stranded DNA substrates. ALKBH3 is one of many homologs of the Escherichia coli protein, AlkB. ALKBH3 is expressed in a wide variety of tissues and localizes to the cytoplasm and the nucleus. It associates with iron and 2-oxoglutarate, coupling the oxidation of substrates to the conversion of 2-oxoglutarate into succinate and CO2. Via oxidative demethylation, ALKBH3 repairs 1-methyladenine and 3-methylcytosine lesions in alkylated DNA and RNA. Its activity is stimulated by ascorbate. Two isoforms exist for ALKBH3 due to alternative splicing of the gene.
Alternative Name:
ABH3, AlkB homolog 3, alkB, alkylation repair homolog 3 (E. coli), ALKB3_HUMAN, ALKBH3, Alkylated DNA repair protein alkB homolog 3, alkylation repair homolog 3, Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3, DEPC 1, DEPC-1, DEPC1, EC 1.14.11., FLJ43614, mABH3, MGC118790, MGC118792, MGC118793, MGC134125, PCA1, Prostate cancer antigen 1, prostate cancer antigen-1, RP23-375N21.4,
Application Dilution: WB: 1:500~1:2000
Specificity: ALKBH3 polyclonal antibody detects endogenous levels of ALKBH3 protein.
Immunogen:
Recombinant full length Human ALKBH3.
MW: ~ 33 kDa
Swis Prot.: Q96Q83
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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