ALPK1 polyclonal, anti-human

Background:
The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions in eukaryotes, including cell division, homeostasis and apoptosis. α-protein kinase 1, also known as ALPK1, LAK or KIAA1527, is a 1,244 amino acid protein that contains one α-type protein kinase domain and belongs to the protein kinase superfamily. Expressed at high levels in liver, α-protein kinase 1 recognizes and phosphorylates specific phosphorylation sites that are surrounded by peptides which have an å-helical conformation. One of the targets of å-protein kinase 1 is Myosin I and, via its ability to phosphorylate Myosin I, α-protein kinase 1 is thought to play an important role in the apical trafficking of vesicles carrying raft-associated sucrase-isomaltase (SI).

Alternative Name:
Alpha-protein kinase 1, Chromosome 4 kinase, Lymphocyte alpha-protein kinase

Application Dilution: WB: 1:500~1:1000

Specificity: ALPK1 polyclonal antibody detects endogenous levels of ALPK1 protein.

Immunogen:
Synthetic peptide, corresponding to amino acids 11-55 of Human ALPK1

MW: ~ 139 kDa

Swis Prot.: Q96QP1

Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE)

Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.

Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

For research use only, not for use in diagnostic procedure.