ARHGEF10 polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS5619
Background:
ARHGEF10 (rho guanine nucleotide exchange factor 10), also known as GEF10 or KIAA0294, is a 1,369 amino acid protein that contains one DBL-homology domain and is thought to play a role in myelination of peripheral nerves, specifically during development. ARHGEF10 is expressed as four alternatively spliced isoforms that are present at low levels in ovary, lung, testis and kidney, with considerably higher expression in the central and peripheral nervous systems. Defects in the gene encoding ARHGEF10 are the cause of slowed nerve conduction velocity (SNCV), an autosomal dominant disorders that is characterized by a reduction in nerve velocities resulting from lack of proper myelination.
Alternative Name:
Rho guanine nucleotide exchange factor 10, ARHGEF10, KIAA0294
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200
Specificity: ARHGEF10 polyclonal antibody detects endogenous levels of ARHGEF10 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human ARHGEF10.
MW: ~ 152 kDa
Swis Prot.: O15013
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
ARHGEF10 (rho guanine nucleotide exchange factor 10), also known as GEF10 or KIAA0294, is a 1,369 amino acid protein that contains one DBL-homology domain and is thought to play a role in myelination of peripheral nerves, specifically during development. ARHGEF10 is expressed as four alternatively spliced isoforms that are present at low levels in ovary, lung, testis and kidney, with considerably higher expression in the central and peripheral nervous systems. Defects in the gene encoding ARHGEF10 are the cause of slowed nerve conduction velocity (SNCV), an autosomal dominant disorders that is characterized by a reduction in nerve velocities resulting from lack of proper myelination.
Alternative Name:
Rho guanine nucleotide exchange factor 10, ARHGEF10, KIAA0294
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200
Specificity: ARHGEF10 polyclonal antibody detects endogenous levels of ARHGEF10 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human ARHGEF10.
MW: ~ 152 kDa
Swis Prot.: O15013
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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