ARL4 Antibody (N-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP2307a
Background:
ADP-ribosylation factors (ARFs) regulate intracellular vesicular membrane trafficking and stimulate a phospholipase D isoform. ARL (ADP-ribosylation like factor) proteins are very similar in sequence to ARFs. ARFs and ARF-like (ARL) proteins, which share sequence similarity with ARFs, form a subfamily of the Ras-related GTPase superfamily. A number of experiments from different laboratories have pointed to a role for ARL4 in sperm production. Mice lacking Arl4 do not have upregulated expression of other Arl genes in testis, were viable and exhibited normal fertility, but presented reduced testicular weight and sperm count. It has been proposed that ARL4 is required for the progression of cells through meiosis and that ARL4 deletion retards production of haploid spermatides.
Other Names:
ADP-ribosylation factor-like protein 4A, ARL4A, ARL4
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP2307a was selected from the N-term region of human ARL4 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: ARL4A
Gene ID: 10124
Primary Accession: P40617
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
ADP-ribosylation factors (ARFs) regulate intracellular vesicular membrane trafficking and stimulate a phospholipase D isoform. ARL (ADP-ribosylation like factor) proteins are very similar in sequence to ARFs. ARFs and ARF-like (ARL) proteins, which share sequence similarity with ARFs, form a subfamily of the Ras-related GTPase superfamily. A number of experiments from different laboratories have pointed to a role for ARL4 in sperm production. Mice lacking Arl4 do not have upregulated expression of other Arl genes in testis, were viable and exhibited normal fertility, but presented reduced testicular weight and sperm count. It has been proposed that ARL4 is required for the progression of cells through meiosis and that ARL4 deletion retards production of haploid spermatides.
Other Names:
ADP-ribosylation factor-like protein 4A, ARL4A, ARL4
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP2307a was selected from the N-term region of human ARL4 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: ARL4A
Gene ID: 10124
Primary Accession: P40617
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
| Is Featured? | No |
|---|
Write Your Own Review