Arrestin-β-2 polyclonal, anti-human
€388.00
In stock
SKU
BS6206
Background:
Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins.
Alternative Name:
ARB 2, ARB2, ARR 2, ARR2, ARRB 2, ARRB2, ARRB2_HUMAN, Arrestin 3, Arrestin beta 2, Arrestin beta-2, BARR2, Beta-arrestin-2, DKFZp686L0365, HGNC:712,
Application Dilution: WB: 1:500 - 1:2000
Specificity: Arrestin-β-2 polyclonal antibody detects endogenous levels of Arrestin-β-2 protein.
Immunogen:
Recombinant full length Human Arrestin-β-2.
MW: ~ 52 kDa
Swis Prot.: P32121
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins.
Alternative Name:
ARB 2, ARB2, ARR 2, ARR2, ARRB 2, ARRB2, ARRB2_HUMAN, Arrestin 3, Arrestin beta 2, Arrestin beta-2, BARR2, Beta-arrestin-2, DKFZp686L0365, HGNC:712,
Application Dilution: WB: 1:500 - 1:2000
Specificity: Arrestin-β-2 polyclonal antibody detects endogenous levels of Arrestin-β-2 protein.
Immunogen:
Recombinant full length Human Arrestin-β-2.
MW: ~ 52 kDa
Swis Prot.: P32121
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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