ASM polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS60373
Background:
Acid sphingomyelinase (ASM) is a lysosomal protein that hydrolyzes sphingomyelin to ceramide and phosphocholine. The ASM gene encodes three proteins, ASM-1, ASM-2 and ASM-3, of which ASM-1 is the only ASM gene product that is a catalytically active enzyme. Deficiency of ASM is associated with type A and type B Niemann-Pick disease. Type A is a fatal neurodegenerative disorder seen in infancy and resulting in death by age three, whereas type B is a non-neuropathic disease that has a later onset. During monocytic cell differentiation, the expression of ASM is upregulated by the combined actions of AP-2 and Sp1 transcription factors.
Alternative Name:
Sphingomyelin phosphodiesterase, Acid sphingomyelinase, aSMase, SMPD1
Application Dilution: WB: 1:500~1:1000
Specificity: ASM polyclonal antibody detects endogenous levels of Acid sphingomyelinase protein.
Immunogen:
A synthetic peptide corresponding to residues in Human ASM.
MW: ~ 65 kDa
Swis Prot.: P17405
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Acid sphingomyelinase (ASM) is a lysosomal protein that hydrolyzes sphingomyelin to ceramide and phosphocholine. The ASM gene encodes three proteins, ASM-1, ASM-2 and ASM-3, of which ASM-1 is the only ASM gene product that is a catalytically active enzyme. Deficiency of ASM is associated with type A and type B Niemann-Pick disease. Type A is a fatal neurodegenerative disorder seen in infancy and resulting in death by age three, whereas type B is a non-neuropathic disease that has a later onset. During monocytic cell differentiation, the expression of ASM is upregulated by the combined actions of AP-2 and Sp1 transcription factors.
Alternative Name:
Sphingomyelin phosphodiesterase, Acid sphingomyelinase, aSMase, SMPD1
Application Dilution: WB: 1:500~1:1000
Specificity: ASM polyclonal antibody detects endogenous levels of Acid sphingomyelinase protein.
Immunogen:
A synthetic peptide corresponding to residues in Human ASM.
MW: ~ 65 kDa
Swis Prot.: P17405
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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