BAMBI polyclonal, anti-human, rat
€388.00
In stock
SKU
BS6435
Background:
BAMBI (BMP and activin membrane-bound inhibitor homolog, NMA), also designated Non-metastatic gene A protein, is a membrane spanning glycoprotein that acts as a negative regulator of TGF-β signaling during development. The BAMBI family of proteins are related to type I TGF-β receptor family, however, BAMBI is a pseudoreceptor that lacks an intracellular serine/threonine kinase domain. BAMBI transcription regulation is under the influence of β-catenin, BMP, smad3 and smad4. BAMBI expression can increase in colorectal and hepatocellular carcinomas relative to non-cancerous tissues. BAMBI is expressed at high levels during odontogenesis. BAMBI is coexpressed with Bmp-4 during early Xenopus embryogenesis and can be detected in poorly metastatic human melanoma cell lines.
Alternative Name:
BMP and activin membrane-bound inhibitor homolog, Non-metastatic gene A protein, Putative transmembrane protein NMA, BAMBI, NMA
Application Dilution: WB: 1:500~1:2000, IF: 1:50~1:200
Specificity: BAMBI polyclonal antibody detects endogenous levels of BAMBI protein.
Immunogen:
Recombinant full length Human BAMBI.
MW: ~ 29 kDa
Swis Prot.: Q13145
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
BAMBI (BMP and activin membrane-bound inhibitor homolog, NMA), also designated Non-metastatic gene A protein, is a membrane spanning glycoprotein that acts as a negative regulator of TGF-β signaling during development. The BAMBI family of proteins are related to type I TGF-β receptor family, however, BAMBI is a pseudoreceptor that lacks an intracellular serine/threonine kinase domain. BAMBI transcription regulation is under the influence of β-catenin, BMP, smad3 and smad4. BAMBI expression can increase in colorectal and hepatocellular carcinomas relative to non-cancerous tissues. BAMBI is expressed at high levels during odontogenesis. BAMBI is coexpressed with Bmp-4 during early Xenopus embryogenesis and can be detected in poorly metastatic human melanoma cell lines.
Alternative Name:
BMP and activin membrane-bound inhibitor homolog, Non-metastatic gene A protein, Putative transmembrane protein NMA, BAMBI, NMA
Application Dilution: WB: 1:500~1:2000, IF: 1:50~1:200
Specificity: BAMBI polyclonal antibody detects endogenous levels of BAMBI protein.
Immunogen:
Recombinant full length Human BAMBI.
MW: ~ 29 kDa
Swis Prot.: Q13145
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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