BCL2 polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS70205
Background:
Bcl-2 is one among many key regulators of apoptosis which are essential for proper development, tissue homeostasis and protection against foreign pathogens. Human Bcl-2 is a 26 kDa, membraneassociated, anti-apoptotic oncoprotein that can promote cell survival through protein-protein interactions with other Bcl-2 related family members, such as the death suppressors Bcl-xL, Mcl-1, Bcl-w and A1, or the death agonists Bax, Bak, Bik, Bad and BID. The anti-apoptotic function of Bcl-2 can also be regulated through proteolytic processing and phosphorylation. Bcl-2 may promote cell survival by interfering with the activation of the cytochrome c/Apaf-1 pathway through stabilization of the mitochondrial membrane.
Alternative Name:
BCL2,Bcl-2 ,ONCOGENE B-CELL LEUKEMIA 2, Apoptosis regulator Bcl-2
Application Dilution: WB: 1:500 - 1:2000, IHC: 1:50 - 1:100
Specificity: BCL2 polyclonal antibody detects endogenous levels of BCL2 protein.
Immunogen:
A synthetic peptide of human BCL2.
MW: ~ 26 kDa
Swis Prot.: P10415
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Bcl-2 is one among many key regulators of apoptosis which are essential for proper development, tissue homeostasis and protection against foreign pathogens. Human Bcl-2 is a 26 kDa, membraneassociated, anti-apoptotic oncoprotein that can promote cell survival through protein-protein interactions with other Bcl-2 related family members, such as the death suppressors Bcl-xL, Mcl-1, Bcl-w and A1, or the death agonists Bax, Bak, Bik, Bad and BID. The anti-apoptotic function of Bcl-2 can also be regulated through proteolytic processing and phosphorylation. Bcl-2 may promote cell survival by interfering with the activation of the cytochrome c/Apaf-1 pathway through stabilization of the mitochondrial membrane.
Alternative Name:
BCL2,Bcl-2 ,ONCOGENE B-CELL LEUKEMIA 2, Apoptosis regulator Bcl-2
Application Dilution: WB: 1:500 - 1:2000, IHC: 1:50 - 1:100
Specificity: BCL2 polyclonal antibody detects endogenous levels of BCL2 protein.
Immunogen:
A synthetic peptide of human BCL2.
MW: ~ 26 kDa
Swis Prot.: P10415
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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