BCLAF1 polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS61571
Background:
Apoptosis defines a set of cascades which, when initiated, programs the cell to undergo lethal changes such as membrane blebbing, mitochondrial breakdown and DNA fragmentation. Bcl-2 is one of many key regulators of apoptosis which are essential for proper development, tissue homeostasis and protection against foreign pathogens. BCLAF1 (BCL2-associated transcription factor 1), also known as BTF, is a 920 amino acid protein that localizes to both the nucleus and the cytoplasm. Expressed throughout the body, BCLAF1 functions as a death-promoting factor that interacts with and represses the transcription of Bcl-2, thereby influencing the regulation of apoptosis. Overexpression of BCLAF1 results in the relocation of BCLAF1 to the nuclear envelope and the subsequent induction of apoptosis, an event that may occur as a result of DNA damage. Four isoforms of BCLAF1 exist due to alternative splicing events.
Alternative Name:
Bcl-2-associated transcription factor 1, Btf
Application Dilution: WB: 1:500~1:1000
Specificity: BCLAF1 polyclonal antibody detects endogenous levels of BCLAF1 protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 286-330 of Human BCLAF1
MW: ~ 150 kDa
Swis Prot.: Q9NYF8
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE)
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Apoptosis defines a set of cascades which, when initiated, programs the cell to undergo lethal changes such as membrane blebbing, mitochondrial breakdown and DNA fragmentation. Bcl-2 is one of many key regulators of apoptosis which are essential for proper development, tissue homeostasis and protection against foreign pathogens. BCLAF1 (BCL2-associated transcription factor 1), also known as BTF, is a 920 amino acid protein that localizes to both the nucleus and the cytoplasm. Expressed throughout the body, BCLAF1 functions as a death-promoting factor that interacts with and represses the transcription of Bcl-2, thereby influencing the regulation of apoptosis. Overexpression of BCLAF1 results in the relocation of BCLAF1 to the nuclear envelope and the subsequent induction of apoptosis, an event that may occur as a result of DNA damage. Four isoforms of BCLAF1 exist due to alternative splicing events.
Alternative Name:
Bcl-2-associated transcription factor 1, Btf
Application Dilution: WB: 1:500~1:1000
Specificity: BCLAF1 polyclonal antibody detects endogenous levels of BCLAF1 protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 286-330 of Human BCLAF1
MW: ~ 150 kDa
Swis Prot.: Q9NYF8
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE)
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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