BMP3 polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS5629
Background:
Bone morphogenic proteins (BMPs) are members of the TGFβ superfamily. BMPs are involved in the induction of cartilage and bone formation. In vivo studies have shown that BMP-2 (also designated BMP-2A) and BMP-3 can independently induce cartilage formation. Smad3 association with the TGFβ receptor complex and Smad1 translocation to the nucleus are observed after the addition of BMP-4 (also designated BMP-2B), suggesting that BMP-4 may play a role in activation of the Smad pathway. BMP-5, BMP-6 and BMP-7 all share high sequence homology with BMP-2, indicating that they each may be able to induce cartilage formation. BMP-8 (also designated OP-2) is thought to be involved in early development, as detectable expression has not been found in adult organs.
Alternative Name:
Bone morphogenetic protein 3, BMP-3, Bone morphogenetic protein 3A, BMP-3A, Osteogenin, BMP3A, BMP3
Application Dilution: WB: 1:500~1:1000, ICC: 1:50~1:200
Specificity: BMP3 polyclonal antibody detects endogenous levels of BMP3 protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 329-374 of Human BMP-3.
MW: ~ 54 kDa
Swis Prot.: P12645
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Bone morphogenic proteins (BMPs) are members of the TGFβ superfamily. BMPs are involved in the induction of cartilage and bone formation. In vivo studies have shown that BMP-2 (also designated BMP-2A) and BMP-3 can independently induce cartilage formation. Smad3 association with the TGFβ receptor complex and Smad1 translocation to the nucleus are observed after the addition of BMP-4 (also designated BMP-2B), suggesting that BMP-4 may play a role in activation of the Smad pathway. BMP-5, BMP-6 and BMP-7 all share high sequence homology with BMP-2, indicating that they each may be able to induce cartilage formation. BMP-8 (also designated OP-2) is thought to be involved in early development, as detectable expression has not been found in adult organs.
Alternative Name:
Bone morphogenetic protein 3, BMP-3, Bone morphogenetic protein 3A, BMP-3A, Osteogenin, BMP3A, BMP3
Application Dilution: WB: 1:500~1:1000, ICC: 1:50~1:200
Specificity: BMP3 polyclonal antibody detects endogenous levels of BMP3 protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 329-374 of Human BMP-3.
MW: ~ 54 kDa
Swis Prot.: P12645
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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