C21orf33 polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS8210
Background:
KNP-I (ES1 protein homolog, protein GT335) is a ubiquitously expressed mitochondrial protein that belongs to the ES1 family of proteins. It is a highly conserved protein with homologs identified in various species. This conserved nature suggests an important biological role for the KNP-I protein. The gene that encodes KNP-I (C21orf33) is located on human chromosome 21 in close proximity to a region (D21S25) associated with many genetic diseases. Down syndrome (DS), caused by an extra copy of chromosome 21, is the most common manifestation of trisomic chromosomes. It is likely that the overproduction of the C21orf33 gene product plays a role in the pathology of DS, while its chromosomal location suggests its likely involvement in D21S25 related diseases. While expressed in most tissue, highest expression of KNP-I is found in heart and muscle.
Alternative Name:
ES1 protein homolog, mitochondrial, Protein GT335, Protein KNP-I, C21orf33, HES1, KNPI
Application Dilution: WB: 1:500 - 1:2000, IF: 1:10 - 1:100
Specificity: C21orf33 polyclonal antibody detects endogenous levels of C21orf33 protein.
Immunogen:
Recombinant full length Human C21orf33.
MW: ~ 28 kDa
Swis Prot.: P30042
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
KNP-I (ES1 protein homolog, protein GT335) is a ubiquitously expressed mitochondrial protein that belongs to the ES1 family of proteins. It is a highly conserved protein with homologs identified in various species. This conserved nature suggests an important biological role for the KNP-I protein. The gene that encodes KNP-I (C21orf33) is located on human chromosome 21 in close proximity to a region (D21S25) associated with many genetic diseases. Down syndrome (DS), caused by an extra copy of chromosome 21, is the most common manifestation of trisomic chromosomes. It is likely that the overproduction of the C21orf33 gene product plays a role in the pathology of DS, while its chromosomal location suggests its likely involvement in D21S25 related diseases. While expressed in most tissue, highest expression of KNP-I is found in heart and muscle.
Alternative Name:
ES1 protein homolog, mitochondrial, Protein GT335, Protein KNP-I, C21orf33, HES1, KNPI
Application Dilution: WB: 1:500 - 1:2000, IF: 1:10 - 1:100
Specificity: C21orf33 polyclonal antibody detects endogenous levels of C21orf33 protein.
Immunogen:
Recombinant full length Human C21orf33.
MW: ~ 28 kDa
Swis Prot.: P30042
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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