C4A/C4B polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS60394
Background:
The complement component proteins C3, C4 and C5 are potent anaphylatoxins that are released during complement activation, a system of ligand-surface protein interactions specific to cells of hematopoietic lineage. These proteins belong to theα2-macroglobulin family, but retain distinctive features including an anaphylatoxin domain and a netrin (NTR) domain. The human C4 gene is polymorphic at two loci, C4A and C4B,mapping to chromosome 6p21.32. C4A expressesthe Rodgers(Rg) blood group Ag, while C4B expresses the Chido(Ch) blood group Ag. C4 is expressed as a precursor that iscleaved into α, β and γ chains, all ofwhich are non-identica lcleavage products. Theαchain of C4 may be cleaved to produce an acidic isotype, C4a,which reactswith amino groups, and a basicisotype, C4b,which reacts with hydroxyl groups. Deficiency in the C4 gene is associated with autoimmune or immune complex disorders, such assystemic lupus erythematosus.
Alternative Name:
Complement C4-A, Acidic complement C4, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2, Complement C4 beta chain, Complement C4-A alpha chain, C4a anaphylatoxin, C4b-A, C4d-A, Complement C4 gamma chain, C4A, CO4, CPAMD2
Application Dilution: WB: 1:500~1:1000
Specificity: C4A/C4B polyclonal antibody detects endogenous levels of C4A and C4B protein.
Immunogen:
A synthetic peptide corresponding to residues in Human C4A.
MW: ~ 193 kDa
Swis Prot.: P0C0L4/P0C0L5
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The complement component proteins C3, C4 and C5 are potent anaphylatoxins that are released during complement activation, a system of ligand-surface protein interactions specific to cells of hematopoietic lineage. These proteins belong to theα2-macroglobulin family, but retain distinctive features including an anaphylatoxin domain and a netrin (NTR) domain. The human C4 gene is polymorphic at two loci, C4A and C4B,mapping to chromosome 6p21.32. C4A expressesthe Rodgers(Rg) blood group Ag, while C4B expresses the Chido(Ch) blood group Ag. C4 is expressed as a precursor that iscleaved into α, β and γ chains, all ofwhich are non-identica lcleavage products. Theαchain of C4 may be cleaved to produce an acidic isotype, C4a,which reactswith amino groups, and a basicisotype, C4b,which reacts with hydroxyl groups. Deficiency in the C4 gene is associated with autoimmune or immune complex disorders, such assystemic lupus erythematosus.
Alternative Name:
Complement C4-A, Acidic complement C4, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2, Complement C4 beta chain, Complement C4-A alpha chain, C4a anaphylatoxin, C4b-A, C4d-A, Complement C4 gamma chain, C4A, CO4, CPAMD2
Application Dilution: WB: 1:500~1:1000
Specificity: C4A/C4B polyclonal antibody detects endogenous levels of C4A and C4B protein.
Immunogen:
A synthetic peptide corresponding to residues in Human C4A.
MW: ~ 193 kDa
Swis Prot.: P0C0L4/P0C0L5
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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