C8orf4 polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS70725
Background:
This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes. The encoded protein may also play a role in the NF-kappaB and ERK1/2 signaling pathways. Expression of this gene may play a role in the proliferation of several types of cancer including thyroid cancer, breast cancer and hematological malignancies.
Alternative Name:
TC1, TC-1, Thyroid cancer protein 1
Application Dilution: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200
Specificity: C8orf4 polyclonal antibody detects endogenous levels of C8orf4 protein.
Immunogen:
Recombinant protein of human C8orf4.
MW: ~ 12 kDa
Swis Prot.: Q9NR00
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes. The encoded protein may also play a role in the NF-kappaB and ERK1/2 signaling pathways. Expression of this gene may play a role in the proliferation of several types of cancer including thyroid cancer, breast cancer and hematological malignancies.
Alternative Name:
TC1, TC-1, Thyroid cancer protein 1
Application Dilution: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200
Specificity: C8orf4 polyclonal antibody detects endogenous levels of C8orf4 protein.
Immunogen:
Recombinant protein of human C8orf4.
MW: ~ 12 kDa
Swis Prot.: Q9NR00
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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