CA6 polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS5637
Background:
Carbonic anhydrase VI (CA VI) contributes to taste function when secreted in the saliva by protecting taste receptor cells (TRCs) from apoptosis. Functional CA VI exists as a single polypeptide chain tightly bound to one molecule of zinc, and containing two N-linked glycosylation sites. Decreased CA VI secretion correlates with loss of taste (hypogeusia) and smell (hyposmia) or distorted taste (dysgeusia) and smell (dysosmia), and altered taste bud morphology. Addition of zinc to individuals experiencing these symptoms restored secretion of CA VI to normal levels and normal taste bud morphology in some, but not all, cases, indicating two different mechanisms leading to CA VI dysfunction.
Alternative Name:
Carbonic anhydrase 6, Carbonic anhydrase6, Carbonate dehydratase VI, Carbonic anhydrase VI, CA-VI, Salivary carbonic anhydrase, Secreted carbonic anhydrase, CA-6
Application Dilution: WB: 1:500~1:1000, ICC: 1:50~1:200
Specificity: CA6 polyclonal antibody detects endogenous levels of Carbonic anhydrase 6 protein.
Immunogen:
Synthetic peptide, corresponding to the 263-308 of Human CA6.
MW: ~ 37 kDa (glycosylated), ~ 33 kDa (deglycosylated)
Swis Prot.: P23280
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Carbonic anhydrase VI (CA VI) contributes to taste function when secreted in the saliva by protecting taste receptor cells (TRCs) from apoptosis. Functional CA VI exists as a single polypeptide chain tightly bound to one molecule of zinc, and containing two N-linked glycosylation sites. Decreased CA VI secretion correlates with loss of taste (hypogeusia) and smell (hyposmia) or distorted taste (dysgeusia) and smell (dysosmia), and altered taste bud morphology. Addition of zinc to individuals experiencing these symptoms restored secretion of CA VI to normal levels and normal taste bud morphology in some, but not all, cases, indicating two different mechanisms leading to CA VI dysfunction.
Alternative Name:
Carbonic anhydrase 6, Carbonic anhydrase6, Carbonate dehydratase VI, Carbonic anhydrase VI, CA-VI, Salivary carbonic anhydrase, Secreted carbonic anhydrase, CA-6
Application Dilution: WB: 1:500~1:1000, ICC: 1:50~1:200
Specificity: CA6 polyclonal antibody detects endogenous levels of Carbonic anhydrase 6 protein.
Immunogen:
Synthetic peptide, corresponding to the 263-308 of Human CA6.
MW: ~ 37 kDa (glycosylated), ~ 33 kDa (deglycosylated)
Swis Prot.: P23280
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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