CAPN3 polyclonal, anti-human, rat
€305.00
In stock
SKU
BS60732
Background:
Calpain, an intracellular calcium-dependent protease that cleaves cytoskeletal and submembranous proteins, plays a role in cytoskeletal reorganization and muscle protein degradation . Calpain is a heterodimer composed of a small regulatory subunit and one of three large catalytic subunits, designated calpain 1, calpain 2 and calpain 3 . Calpain 3 (calpain p94) is a muscle-preferred calcium activated neutral protease that localizes to the nucleus. The gene encoding human calpain 3 maps to chromosome 15q15.1-q21.1. Mutations involving the calpain 3 gene are associated with limb-girdle muscle dystrophy type 2A, a form of autosomal recessive and progressive neuromuscular disorder. Calpastatin regulates calpain by inhibiting both the proteolytic activity of calpain and its binding to membranes . Calpastatin exists in two types, tissue type and erythrocyte type, resulting from both alternative splicing and proteolytic processing .
Alternative Name:
Calpain-3, Calcium-activated neutral proteinase 3, CANP 3, Calpain L3, Calpain p94, Muscle-specific calcium-activated neutral protease 3, New calpain 1, nCL-1, CAPN3, CANP3, CANPL3, NCL,1
Application Dilution: WB: 1:500~1:1000
Specificity: CAPN3 polyclonal antibody detects endogenous levels of CAPN3 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human CAPN3
MW: ~ 94 kDa
Swis Prot.: P20807
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Calpain, an intracellular calcium-dependent protease that cleaves cytoskeletal and submembranous proteins, plays a role in cytoskeletal reorganization and muscle protein degradation . Calpain is a heterodimer composed of a small regulatory subunit and one of three large catalytic subunits, designated calpain 1, calpain 2 and calpain 3 . Calpain 3 (calpain p94) is a muscle-preferred calcium activated neutral protease that localizes to the nucleus. The gene encoding human calpain 3 maps to chromosome 15q15.1-q21.1. Mutations involving the calpain 3 gene are associated with limb-girdle muscle dystrophy type 2A, a form of autosomal recessive and progressive neuromuscular disorder. Calpastatin regulates calpain by inhibiting both the proteolytic activity of calpain and its binding to membranes . Calpastatin exists in two types, tissue type and erythrocyte type, resulting from both alternative splicing and proteolytic processing .
Alternative Name:
Calpain-3, Calcium-activated neutral proteinase 3, CANP 3, Calpain L3, Calpain p94, Muscle-specific calcium-activated neutral protease 3, New calpain 1, nCL-1, CAPN3, CANP3, CANPL3, NCL,1
Application Dilution: WB: 1:500~1:1000
Specificity: CAPN3 polyclonal antibody detects endogenous levels of CAPN3 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human CAPN3
MW: ~ 94 kDa
Swis Prot.: P20807
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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