Caspase 14 p10 polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS5643
Background:
Caspases are a family of cysteine proteases that play an essential role in carrying out apoptosis. Caspase-14, also named MICE, is a unique member of the caspase family with restricted expression; it is found in embryonic tissues and adult skin. Caspase-14 is weakly processed into p19 and p10 subunits by caspase-8. Caspase-14 may not play a role in apoptosis, but instead may regulate keratinocyte differentiation. Expression of caspase-14 may protect from psoriasis and irradiation damage. Caspase-14 may also be responsible for proteolytic processing of filaggrin during terminal differentiation of keratinocytes.
Alternative Name:
Caspase14, Caspase-14, CASP-14, Caspase-14 subunit p10, CASP14
Application Dilution: WB: 1:500~1:1000
Specificity: Caspase 14 p10 polyclonal antibody recognizes endogenous levels of total caspase-14 protein and the p10 subunit of mature caspase-14.
Immunogen:
Synthetic peptide, corresponding to amino acids 163-208 of Human Caspase 14.
MW: ~ 10, 27 kDa
Swis Prot.: P31944
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Caspases are a family of cysteine proteases that play an essential role in carrying out apoptosis. Caspase-14, also named MICE, is a unique member of the caspase family with restricted expression; it is found in embryonic tissues and adult skin. Caspase-14 is weakly processed into p19 and p10 subunits by caspase-8. Caspase-14 may not play a role in apoptosis, but instead may regulate keratinocyte differentiation. Expression of caspase-14 may protect from psoriasis and irradiation damage. Caspase-14 may also be responsible for proteolytic processing of filaggrin during terminal differentiation of keratinocytes.
Alternative Name:
Caspase14, Caspase-14, CASP-14, Caspase-14 subunit p10, CASP14
Application Dilution: WB: 1:500~1:1000
Specificity: Caspase 14 p10 polyclonal antibody recognizes endogenous levels of total caspase-14 protein and the p10 subunit of mature caspase-14.
Immunogen:
Synthetic peptide, corresponding to amino acids 163-208 of Human Caspase 14.
MW: ~ 10, 27 kDa
Swis Prot.: P31944
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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