Caspase 14 polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS8531
Background:
Caspases are a family of cysteine proteases that play an essential role in carrying out apoptosis. Caspase-14, also named MICE, is a unique member of the caspase family with restricted expression; it is found in embryonic tissues and adult skin. Caspase-14 is weakly processed into p19 and p10 subunits by caspase-8. Caspase-14 may not play a role in apoptosis, but instead may regulate keratinocyte differentiation. Expression of caspase-14 may protect from psoriasis and irradiation damage. Caspase-14 may also be responsible for proteolytic processing of filaggrin during terminal differentiation of keratinocytes.
Alternative Name:
Caspase14, Caspase-14, CASP-14, Caspase-14 subunit p10, CASP14
Application Dilution: WB: 1:500 - 1:2000, IF: 1:10 - 1:100
Specificity: Caspase 14 polyclonal antibody detects endogenous levels of Caspase 14 protein.
Immunogen:
Recombinant full length Human Caspase 14.
MW: ~ 27kDa
Swis Prot.: P31944
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Caspases are a family of cysteine proteases that play an essential role in carrying out apoptosis. Caspase-14, also named MICE, is a unique member of the caspase family with restricted expression; it is found in embryonic tissues and adult skin. Caspase-14 is weakly processed into p19 and p10 subunits by caspase-8. Caspase-14 may not play a role in apoptosis, but instead may regulate keratinocyte differentiation. Expression of caspase-14 may protect from psoriasis and irradiation damage. Caspase-14 may also be responsible for proteolytic processing of filaggrin during terminal differentiation of keratinocytes.
Alternative Name:
Caspase14, Caspase-14, CASP-14, Caspase-14 subunit p10, CASP14
Application Dilution: WB: 1:500 - 1:2000, IF: 1:10 - 1:100
Specificity: Caspase 14 polyclonal antibody detects endogenous levels of Caspase 14 protein.
Immunogen:
Recombinant full length Human Caspase 14.
MW: ~ 27kDa
Swis Prot.: P31944
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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