Caspase 5 p10 polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS5645
Background:
Caspase-5 (also designated ICErel-III, TY, ICH-3 and caspase-12 in mouse), can cleave its own precursor, an activity that requires the cysteine 245 residue. Frameshift mutations in caspase-5 have been identified in MMP tumors of the endometrium, colon, and stomach, indicating the caspase-5 may be a new target gene in the microsatellite mutator pathway for cancer. The human caspase 5 gene maps to chromosome 11q22.2-q22.3 and encodes a protein whose expression is barely detectable in most tissues except brain, with highest expression levels being found in lung, liver and skeletal muscle.
Alternative Name:
Caspase-5, CASP-5, ICE(rel)-III, Protease ICH-3, Protease TY, Caspase-5 subunit p10, CASP5, ICH3, Caspase5
Application Dilution: WB: 1:500~1:1000
Specificity: Caspase 5 p10 polyclonal antibody recognizes endogenous levels of total caspase-5 protein and the p10 subunit of mature caspase-5.
Immunogen:
Synthetic peptide, corresponding to amino acids 341-386 of Human Caspase-5.
MW: ~ 10, 48 kDa
Swis Prot.: P51878
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Caspase-5 (also designated ICErel-III, TY, ICH-3 and caspase-12 in mouse), can cleave its own precursor, an activity that requires the cysteine 245 residue. Frameshift mutations in caspase-5 have been identified in MMP tumors of the endometrium, colon, and stomach, indicating the caspase-5 may be a new target gene in the microsatellite mutator pathway for cancer. The human caspase 5 gene maps to chromosome 11q22.2-q22.3 and encodes a protein whose expression is barely detectable in most tissues except brain, with highest expression levels being found in lung, liver and skeletal muscle.
Alternative Name:
Caspase-5, CASP-5, ICE(rel)-III, Protease ICH-3, Protease TY, Caspase-5 subunit p10, CASP5, ICH3, Caspase5
Application Dilution: WB: 1:500~1:1000
Specificity: Caspase 5 p10 polyclonal antibody recognizes endogenous levels of total caspase-5 protein and the p10 subunit of mature caspase-5.
Immunogen:
Synthetic peptide, corresponding to amino acids 341-386 of Human Caspase-5.
MW: ~ 10, 48 kDa
Swis Prot.: P51878
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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