Catenin-α1 polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS6976
Background:
α E-catenin (also designated α-catenin; cadherin-associated protein, alpha 1, 102kDa; and CAP102) plays a role in E-cadherin mediated cell-cell adhesion by linking E-cadherin to the cytoskeleton via β- or γ-catenin and Actin. α E-catenin connects cell-density-dependent adherens junctions with the developmental hedgehog pathway and may provide a negative feedback loop controlling the size of developing cerebral cortex. It is abundant in neuroepithelial precursor cells in the developing cortical ventricular zone of the brain, with reduced expression in the cortical plate. α E-catenin-vinculin interactions play a role in the assembly of the apical junction complex in epithelia. Catenins generally are thought to work as connectors that anchor E-cadherin to the cytoskeletal Actin bundle through the cadherin cytoplasmic domain. Dysfunction of this adhesion complex causes dissociation of cancer cells from primary tumor nodules, and is thus considered a contributing factor to metastasis.
Alternative Name:
Catenin alpha-1, Alpha E-catenin, Cadherin-associated protein, Renal carcinoma antigen NY-REN-13, CTNNA1, Catenin-α1, Catenin α1, αE-catenin, Catenin alpha-2, Alpha N-catenin, Alpha-catenin-related protein, CTNNA2, CAPR, Catenin-α2, Catenin α2, αN-catenin,
Application Dilution: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IP: 1:50 - 1:100
Specificity: Catenin-α1 polyclonal antibody detects endogenous levels of Catenin-α1 protein.
Immunogen:
Recombinant full length Human Catenin-α1.
MW: ~ 100, 120kDa
Swis Prot.: P35221
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
α E-catenin (also designated α-catenin; cadherin-associated protein, alpha 1, 102kDa; and CAP102) plays a role in E-cadherin mediated cell-cell adhesion by linking E-cadherin to the cytoskeleton via β- or γ-catenin and Actin. α E-catenin connects cell-density-dependent adherens junctions with the developmental hedgehog pathway and may provide a negative feedback loop controlling the size of developing cerebral cortex. It is abundant in neuroepithelial precursor cells in the developing cortical ventricular zone of the brain, with reduced expression in the cortical plate. α E-catenin-vinculin interactions play a role in the assembly of the apical junction complex in epithelia. Catenins generally are thought to work as connectors that anchor E-cadherin to the cytoskeletal Actin bundle through the cadherin cytoplasmic domain. Dysfunction of this adhesion complex causes dissociation of cancer cells from primary tumor nodules, and is thus considered a contributing factor to metastasis.
Alternative Name:
Catenin alpha-1, Alpha E-catenin, Cadherin-associated protein, Renal carcinoma antigen NY-REN-13, CTNNA1, Catenin-α1, Catenin α1, αE-catenin, Catenin alpha-2, Alpha N-catenin, Alpha-catenin-related protein, CTNNA2, CAPR, Catenin-α2, Catenin α2, αN-catenin,
Application Dilution: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IP: 1:50 - 1:100
Specificity: Catenin-α1 polyclonal antibody detects endogenous levels of Catenin-α1 protein.
Immunogen:
Recombinant full length Human Catenin-α1.
MW: ~ 100, 120kDa
Swis Prot.: P35221
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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