Catenin-γ polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS6066
Background:
The catenins, α, β and γ, are proteins which bind to the highly conserved,intracellular cytoplasmic tail of E-cadherin. Together, the catenin/cadherincomplexes play an important role mediating cellular adhesion. α-catenin was initially described as an E-cadherin associated protein, and since has been shown to associate with other members of the cadherin family, such as N-cadherin and P-cadherin. β-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. β-catenin has also been found in complexes with the tumor suppressor protein APC. γ-catenin, also known as plakoglobin, binds with α-catenin and N-cadherin. It has been shown that the transmembrane phosphatase PTPμ associates with catenin/cadherin complexes and may regulate complex signaling.
Alternative Name:
Junction plakoglobin, Catenin gamma, Desmoplakin-3, CTNNG, DP3, Catenin-γ
Application Dilution: WB: 1:500~1:2000, IF: 1:50~1:200, IP 1:50 - 1:100
Specificity: Catenin-γ polyclonal antibody detects endogenous levels of Catenin-γ protein.
Immunogen:
Recombinant full length Human JUP.
MW: ~ 82 kDa
Swis Prot.: P14923
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The catenins, α, β and γ, are proteins which bind to the highly conserved,intracellular cytoplasmic tail of E-cadherin. Together, the catenin/cadherincomplexes play an important role mediating cellular adhesion. α-catenin was initially described as an E-cadherin associated protein, and since has been shown to associate with other members of the cadherin family, such as N-cadherin and P-cadherin. β-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. β-catenin has also been found in complexes with the tumor suppressor protein APC. γ-catenin, also known as plakoglobin, binds with α-catenin and N-cadherin. It has been shown that the transmembrane phosphatase PTPμ associates with catenin/cadherin complexes and may regulate complex signaling.
Alternative Name:
Junction plakoglobin, Catenin gamma, Desmoplakin-3, CTNNG, DP3, Catenin-γ
Application Dilution: WB: 1:500~1:2000, IF: 1:50~1:200, IP 1:50 - 1:100
Specificity: Catenin-γ polyclonal antibody detects endogenous levels of Catenin-γ protein.
Immunogen:
Recombinant full length Human JUP.
MW: ~ 82 kDa
Swis Prot.: P14923
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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