Cathepsin A 20k (M327) polyclonal, anti-human, rat

Background:
The cathepsin family of proteolytic enzymes include several diverse classes of proteases. Cathepsins B, L, H, K, S and O comprise the cysteine protease class. Cathepsins D and E comprise the aspartyle protease class. The serine protease class includes cathepsin G. Cathepsins function in cellular metabolism and participate in peptide biosynthesis and protein degradation. Cathepsin A, a serine carboxypepidase, exists in a high molecular weight lysosomal complex with β-galactosidase (β-Gal) and α-neuraminidase (Neu1). Cathepsin A functions to protect β-Gal and Neu1 from intralysosomal proteolysis. Deficiencies in cathepsin A lead to deficiencies in β-Gal and Neu1. The gene encoding human cathepsin A maps to chromosome 20q13.12. Mutations in this gene cause glactosialidosis, a lysosomal storage disorder resulting from the β-Gal and Neu1 deficiencies.

Alternative Name:
Lysosomal protective protein, Carboxypeptidase C, Carboxypeptidase L, Cathepsin A, Protective protein cathepsin A, PPCA, Protective protein for beta-galactosidase, Lysosomal protective protein 32 kDa chain, Lysosomal protective protein 20 kDa chain, CTSA, PPGB

Application Dilution:
WB: 1:500~1:1000

Specificity: Cathepsin A 20k (M327) polyclonal antibody detects endogenous levels of Cathepsin A 20k protein.

Immunogen:
Synthetic peptide, corresponding to amino acids 327-380 of Human Cathepsin A.

MW: ~ 20 kDa

Swiss-Prot: P10619

Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

For research use only, not for use in diagnostic procedure.