Cathepsin D polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS61763
Background:
Cathepsin D is a ubiquitously expressed lysosomal aspartyl protease involved in the normal degradation of proteins. It is synthesized as an inactive 43 kDa preprocathepsin D that is cleaved and glycosylated to form a 46 kDa procathepsin D and then further cleaved to produce 28 kDa and 15 kDa subunits (heavy and light chains, respectively). Cathepsin D may also be secreted into the cytosol during apoptosis and contribute to cleavage of substrates implicated in the apoptotic pathway. Numerous studies have suggested that cathepsin D plays a role in neuronal degradation and malignant transformation, particularily in breast cancer.
Alternative Name:
Cathepsin D, Cathepsin D light chain, Cathepsin D heavy chain, CTSD, CPSD
Application Dilution: WB: 1:500~1:1000
Specificity: Cathepsin D polyclonal antibody detects endogenous levels of CTSD protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 150-200 of Human CTSD.
MW: ~ 43 kDa
Swis Prot.: P07339
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Cathepsin D is a ubiquitously expressed lysosomal aspartyl protease involved in the normal degradation of proteins. It is synthesized as an inactive 43 kDa preprocathepsin D that is cleaved and glycosylated to form a 46 kDa procathepsin D and then further cleaved to produce 28 kDa and 15 kDa subunits (heavy and light chains, respectively). Cathepsin D may also be secreted into the cytosol during apoptosis and contribute to cleavage of substrates implicated in the apoptotic pathway. Numerous studies have suggested that cathepsin D plays a role in neuronal degradation and malignant transformation, particularily in breast cancer.
Alternative Name:
Cathepsin D, Cathepsin D light chain, Cathepsin D heavy chain, CTSD, CPSD
Application Dilution: WB: 1:500~1:1000
Specificity: Cathepsin D polyclonal antibody detects endogenous levels of CTSD protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 150-200 of Human CTSD.
MW: ~ 43 kDa
Swis Prot.: P07339
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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