Cathepsin H HC (N292) polyclonal, anti-human, mouse, rat

Background:
Cathepsin H (also designated N-benzoylarginine-β-naphthylamide hydrolase, aleurain, cathepsin B3 or cathepsin BA) is a lysosomal cysteine proteinase that mediates degradation of lysosomal proteins. Cathepsin H is a disulfidelinked heavy and light chain dimer produced from a single precursor protein. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Elevated levels of cathepsin H correlates with malignant progression of prostate tumors. Two transcript variants encoding different isoforms have been found for this gene. Full-length and truncated cathepsin H [12 amino acid deletion in the signal peptide region (CTSH∆10-21)] are expressed in prostate tissues, LNCaP, PC-3 and DU-145 prostate cancer cell lines. Cathepsin H mediates maturation of the biologically active surfactant protein-B (SP-B) peptide.

Alternative Name:
Pro-cathepsin H, Cathepsin H mini chain, Cathepsin H, Cathepsin H heavy chain, Cathepsin H light chain, CTSH, CPSB

Application Dilution:
WB: 1:1000~1:2000

Specificity: Cathepsin H HC (N292) polyclonal antibody detects endogenous levels of Cathepsin H HC protein.

Immunogen:
Synthetic peptide, corresponding to amino acids 240-292 of Human Cathepsin H HC.

MW: ~ 19 kDa

Swiss-Prot: P09668

Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

For research use only, not for use in diagnostic procedure.