CD274 (PDL-1) polyclonal, anti-human, mouse, rat

Protein Family: Cell Adhesion Molecules, Cellular Antigens

Pathway and Disease: Immune System, Signaling Molecules and Interaction

Description:
Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. PDL-1 is a B7-related protein that inhibits cell-mediated immune responses by reducing the secretion of IL-2 and IL-10 from memory T cells. This suggests that PDL-1 may be useful in reducing allogenic CD4+ memory T-cell responses to endothelial cells, thereby reducing the likelihood of host immune responses to allografts. At least two isoforms of PDL-1 are known to exist; this antibody is specific to the larger isoform. PDL-1 antibody has no cross-reactivity to PDL-2.

Alternate Names: PDL-1, Programmed cell death 1 ligand 1, programmed death ligand 1, PD-L1, B7-H1, PDCD1 ligand 1, B7 homolog 1, CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1

Application Notes: E: 1:500-1:1,000; WB: 1:1,000-1:2,000; IHC: 1:100-1:500; IF: 1:20-1:50

Accession No.: NP_054862

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human PDL-1.

Format: Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.