CD292 (BMPR1A) polyclonal, anti-human, mouse, rat, xenopus

Protein Family: Cellular Antigens, Enzymes, Protein Kinases, Receptors and Channels

Pathway and Disease: Cancers, Signal Transduction, Signaling Molecules and Interaction

Description:
Upon ligand binding, BMPR1A forms a receptor complex consisting of two type II and two type I transmembrane Ser/Thr kinases. The type I receptors are activated by the type II receptors by using a phosphorylation mechanism, and subsequently bind SMAD transcriptional regulators. Defects in BMPR1A are the cause of juvenile polyposis syndrome, Cowden disease and hereditary mixed polyposis syndrome 2, which lead to gastrointestinal, breast, thyroid, endometrial and colon cancers.

Alternate Names: Bone morphogenetic protein receptor type IA, Serine/threonine-protein kinase receptor R5, SKR5, Activin receptor-like kinase 3, ALK-3, CD292 antigen, BMPR1A, ACVRLK3

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500

Accession No.: P36894, NP_004320

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human BMPR1A.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.