Cdk7 (clone ), anti-human

Protein Family: Enzymes, Protein Kinases

Pathway and Disease: Transcription, Replication and Repair, Cell Growth and Death

Description:
Cyclin-dependent kinase 7 (Cdk7) is the catalytic subunit of the CDK-activating kinase (CAK) complex, a serine-threonine kinase. Cdk7 activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. Cdk7 complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts.

Alternate Names: Cdk7, Cell division protein kinase 7, CDK-activating kinase, CAK, CAK1, TFIIH basal transcription factor complex kinase subunit, 39 kDa protein kinase, p39 Mo15, STK1, CDK7, MO15

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: P50613

Antigen: Recombinant human Cdk7.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 2% BSA with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.