CKIP1 polyclonal, anti-human, mouse, rat

Protein Family: Chaperones and Folding Catalysts, Cytoskeleton Proteins

Pathway and Disease: Cell Growth and Death

Description:
CKIP1 was identified through a yeast-two hybrid screening as a protein that would interact with only one of the two catalytic subunits of the casein kinase 2 complex. CKIP1 is a pleckstrin homology domain-containing protein localized within the nucleus and at the plasma membrane that interacts with CK2alpha but not CK2alpha’, and is thought to play a role in targeting CK2alpha to a particular cellular location. CKIP1 has been implicated in muscle differentiation and the regulation of cell morphology and actin cytoskeleton. CKIP1 can also interact with other proteins such as ATM, an upstream kinase of p53, and recruit the nuclear ATM to the plasma membrane, suggesting CKIP1 may regulate ATM function through re-localizing ATM. CKIP1 can also form a complex with the kinase AKT, leading to a down-regulation of PI3K/AKT signaling and suppression of tumor growth in vivo.

Alternate Names: CKIP1, Casein kinase-2-interacting protein 1, pleckstrin homology domain containing, family O member 1, PLECKHO1

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500

Accession No.: NP_057358

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human CKIP1.

Format: Each vial contains 0.1 ml IgG (1 mg/ml) in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.