CX3CR1 polyclonal, anti-human, mouse, rat

Protein Family: Cytokines, Receptors and Channels

Pathway and Disease: Immune System, Infectious Diseases, Signaling Molecules and Interaction

Description:
CX3CR1 is one of the chemokine receptors that are required as coreceptors for HIV infection. The genes encoding human, murine, and rat CX3CR1 were cloned and designated V28 and CMKBRL1, CX3CR1, and RBS11, respectively. The encoded seven transmembrane protein was recently identified as the receptor for a novel transmembrane molecule, fractalkine, and renamed CX3CR1. Recently, CX3CR1 was found to serve as a coreceptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by fractokine. CX3CR1 mediates leukocyte migration and adhesion. CX3CR1 is expressed in a variety of human tissues and cell lines.

Alternate Names: CX3CR1, V28, CCRL1, GPR13, CMKDR1, GPRV28, CMKBRL1, CX3C chemokine receptor 1, Beta chemokine receptor-like 1, C-X3-C CKR1

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500; FACS: 1:1000-1:10000; IF: 1:100-1:500

Accession No.: NP_001328

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human CX3CR1.

Format: Each vial contains 0.1 ml IgG (1 mg/ml) in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.