Hepatitis C Virus (HCV) NS3 (clone 1B6), anti-virus
€264.00
In stock
SKU
ARP-23-B0001
Catalog Number: 23-B0001
Size: 25 µg
Isotype: Mouse IgG1
Size: 25 µg
Isotype: Mouse IgG1
Decription:
The NS3 serine protease, in association with NS4A, is responsible for the cleavages of the Hepatitis C virus protease complexes NS3-NS4A, NS4A-NS4B, NS4B-NS5A and NS5A-NS5B. NS5B is a RNA-dependent RNA polymerase that plays an essential role in the virus replication. Hepatitis C virus protease NS3-NS4A colocalizes with IPS-1/VISA/MAVS/Cardif in the mitochondrial membrane and has been shown to cleave the TLR3 adapter TRIF and Cardif to eliminate the antiviral signaling pathways. NS3-NS4A represents an important target for anti-HCV drugs.
Synonyms: Nonstructural Protein 3
Clone: 1B6
Isotype: Mouse IgG1
Immunogen: Recombinant hepatitis C virus (HCV) NS3 serine protease domain.
Reactivity: HCV
Specificity: Recognizes HCV NS3 (genotype 1a and 1b) (epitope mapped to NS3 aa 160-193), recognizes NS3 alone or the NS3-4A complex. Does not cross-react with HCV NS3 (genotype 2a). t
Form: Purified, in PBS containing 10% glycerol and 0.02% sodium azide.
Applications: Immunocytochemistry: (paraformaldehyde fixation) (1:50) Western Blot: (1:500)
Working Dilution: Optimal conditions must be determined individually for each application.
Concentration: 1mg/ml
Storage: 2-8C immediate use, or -20C (aliquote)
The NS3 serine protease, in association with NS4A, is responsible for the cleavages of the Hepatitis C virus protease complexes NS3-NS4A, NS4A-NS4B, NS4B-NS5A and NS5A-NS5B. NS5B is a RNA-dependent RNA polymerase that plays an essential role in the virus replication. Hepatitis C virus protease NS3-NS4A colocalizes with IPS-1/VISA/MAVS/Cardif in the mitochondrial membrane and has been shown to cleave the TLR3 adapter TRIF and Cardif to eliminate the antiviral signaling pathways. NS3-NS4A represents an important target for anti-HCV drugs.
Synonyms: Nonstructural Protein 3
Clone: 1B6
Isotype: Mouse IgG1
Immunogen: Recombinant hepatitis C virus (HCV) NS3 serine protease domain.
Reactivity: HCV
Specificity: Recognizes HCV NS3 (genotype 1a and 1b) (epitope mapped to NS3 aa 160-193), recognizes NS3 alone or the NS3-4A complex. Does not cross-react with HCV NS3 (genotype 2a). t
Form: Purified, in PBS containing 10% glycerol and 0.02% sodium azide.
Applications: Immunocytochemistry: (paraformaldehyde fixation) (1:50) Western Blot: (1:500)
Working Dilution: Optimal conditions must be determined individually for each application.
Concentration: 1mg/ml
Storage: 2-8C immediate use, or -20C (aliquote)
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