SMYD1 (clone ), anti-rat

Background:
SMYD1 (SET and MYND domain-containing protein 1), also known as BOP, ZMYND18 or ZMYND22, is a nuclear and cytoplasmic protein that contains one SET domain and one MYND-type zinc finger. Expressed specifically in cardiac and skeletal muscle, SMYD1 functions as a transcription factor that is essential for cardiac morphogenesis and proper cardiomyocyte differentiation. SMYD1 interacts with the histone deacetylases HDAC1, HDAC2 and HDAC3 and, through this interaction, acts as a histone deacetylase-dependent transcriptional repressor. Defects or deletions in the gene encoding SMYD1 lead to retarded maturation of ventricular cardiomyocytes, further implicating SMYD1 as a crucial component of normal cardiac development.

Alternative Name:
CD8 beta opposite zinc finger, MYND domain containing 18, BOP, KMT3D, ZMYND18, ZMYND22, SMYD1

Application Dilution: WB: 1:1000~2000

Specificity: This antibody detects endogenous levels of SMYD1 and does not cross-react with related proteins

Immunogen:
Recombinant full length Human SMYD1.

MW: Predicted band size: 56KDa , Observed band size: 56KDa

Swis Prot.: Q8NB12

Purification & Purity:
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Format:
Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol

Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

For research use only, not for use in diagnostic procedure.