14-3-3 beta (clone J2E9), anti-human

Decription:
The 14-3-3 family plays a key regulatory role in signal transduction, checkpoint control, apoptotic and nutrient-sensing pathways. 14-3-3 proteins are highly conserved and ubiquitously expressed. There are at least seven isoforms,beta, gamma,epsilon, sigma, zeta, tau andtau that have been identified in mammals. The 14-3-3 beta, a subtype of the 14-3-3 proteins, was found in B Cells, brain and liver etc. This 14-3-3 beta has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery.

Synonyms: Tyrosine 3-monocxygenase/tryptopan 5-monooxygenase activation protein, beta polypeptide, 14-3-3 beta, YWHAB, GW128, HS1, KCIP-1, Tyrosine 3-monocxygenase/tryptopan 5-monooxygenase activation protein, beta polypeptide 14 3 3 protein beta/alpha, Brain protein 14 3 3 beta isoform, GW 128, HS 1, KCIP 1, KCIP1, Protein 1054, Protein kinase C inhibitor protein 1, Tyrosine 3 Monooxygenase/Tryptophan 5 Monooxygenase Activation Protein Beta Polypeptide.

Clone: J2E9. Anti-human 14-3-3 beta mAb, clone J2E9, is derived from hybridization of mouse FO myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human YWHAB protein.

Isotype: Mouse IgG2a, k

Immunogen: Recombinant human 14-3-3 beta (1-246aa) purified from E. coli

Reactivity: human

Form: Purified, in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide.

Applications: ELISA, WB (Cell lysate)

NCBI Nr.: NP_003395

Concentration: 0.1 mg/ml

Storage: Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles.

References:
Rodriguez LG., et al., (2005). J Cell Physiol. Jan; 202(1):285-94.
Mils V , et al., (2000). Oncogene. Mar 2; 19(10):1257-65.