14-3-3 σ polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS6305
Background:
14-3-3 s, also known as SFN, stratifin, HME1 or YWHAS, is a secreted adaptor protein that is involved in regulating both general and specific signaling pathways. Expressed predominately in stratified squamous keratinising epithelium, 14-3-3 s is able to bind and modify the activity of a large number of proteins, such as KRT17 (Keratin 17), through recognition of a phosphothreonine or phosphoserine motif. When bound to Keratin 17, for example, 14-3-3 s acts to stimulate the Akt/mTOR signaling pathway by upregulating protein synthesis and cell growth.
Alternative Name:
14-3-3 protein sigma, Epithelial cell marker protein 1, Stratifin, SFN, HME1, YWHAS
Application Dilution: WB: 1:500~1:2000, IHC/IF: 1:50~1:200
Specificity: 14-3-3 σ polyclonal antibody detects endogenous levels of 14-3-3 σ protein.
Immunogen:
Recombinant full length Human 14-3-3 σ.
MW: ~ 30 kDa
Swis Prot.: P31947
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
14-3-3 s, also known as SFN, stratifin, HME1 or YWHAS, is a secreted adaptor protein that is involved in regulating both general and specific signaling pathways. Expressed predominately in stratified squamous keratinising epithelium, 14-3-3 s is able to bind and modify the activity of a large number of proteins, such as KRT17 (Keratin 17), through recognition of a phosphothreonine or phosphoserine motif. When bound to Keratin 17, for example, 14-3-3 s acts to stimulate the Akt/mTOR signaling pathway by upregulating protein synthesis and cell growth.
Alternative Name:
14-3-3 protein sigma, Epithelial cell marker protein 1, Stratifin, SFN, HME1, YWHAS
Application Dilution: WB: 1:500~1:2000, IHC/IF: 1:50~1:200
Specificity: 14-3-3 σ polyclonal antibody detects endogenous levels of 14-3-3 σ protein.
Immunogen:
Recombinant full length Human 14-3-3 σ.
MW: ~ 30 kDa
Swis Prot.: P31947
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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