14-3-3 sigma SFN monoclonal, anti-human, rat
€455.00
In stock
SKU
AC-ABO14129
Catalog Number: AC-ABO14129
Size: 100 µl
Isotype: Rabbit IgG
Applications: WB, IHC
Datasheet
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Size: 100 µl
Isotype: Rabbit IgG
Applications: WB, IHC
Datasheet
Request Information
Description: Anti-14-3-3 sigma SFN Rabbit Monoclonal Antibody . Tested in WB, IHC applications. This antibody reacts with Human, Rat.
Protein Function:
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53..
Other Names: 14-3-3 protein sigma, Epithelial cell marker protein 1, Stratifin, SFN, HME1 {ECO:0000303|PubMed:1390337}
Clone Name(s):
Clone: HBB-19
Subcellular Localization: Cytoplasm. Nucleus. Secreted. May be secreted by a non-classical secretory pathway.
Tissue Specificity: Present mainly in tissues enriched in stratified squamous keratinizing epithelium.
Gene ID: 2810
Immunogen: A synthesized peptide derived from human 14-3-3 sigma
Calculated MW: 27774
Purification: Affinity-chromatography
Format: Liquid
Contents: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
Concentration (mg/ml): Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Storage: Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Protein Function:
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53..
Other Names: 14-3-3 protein sigma, Epithelial cell marker protein 1, Stratifin, SFN, HME1 {ECO:0000303|PubMed:1390337}
Clone Name(s):
Clone: HBB-19
Subcellular Localization: Cytoplasm. Nucleus. Secreted. May be secreted by a non-classical secretory pathway.
Tissue Specificity: Present mainly in tissues enriched in stratified squamous keratinizing epithelium.
Gene ID: 2810
Immunogen: A synthesized peptide derived from human 14-3-3 sigma
Calculated MW: 27774
Purification: Affinity-chromatography
Format: Liquid
Contents: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
Concentration (mg/ml): Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Storage: Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
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