20S Proteasome polyclonal, anti-human, mouse, rat, monkey

Protein Family: Enzymes, Peptidases

Pathway and Disease: Folding, Sorting and Degradation

Description:
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu and Glu adjacent to the cleavage site at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings resulting in a barrel-shaped structure. The 20S core is part of the clastosomes, cellular bodies that contain ubiquitin conjugates, the proteolytically active 20S core and 19S regulatory complexes, and protein substrates of the proteasome.

Alternate Names: Proteasome subunit alpha 1, 2, 3, 4, 5, 6, 7, Proteasome 20S

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500

Accession No.: P25786

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human 20S Proteasome.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.