A Cyclase IX (P974) polyclonal, anti-human
€305.00
In stock
SKU
BS9246
Background:
Classically, adenylyl cyclases respond to receptor-initiated signals, mediated by the Gs and Gi heterotrimeric G proteins. The binding of an agonist to a Gs-coupled receptor (i.e., α β-adrenergic receptor) catalyzes the exchange of GDP (bound to Gα s) for GTP, dissociation of GTP-Gα s from Gbg and Gα s-mediated activation of adenylyl cyclase. The most abundant cerebral adenylyl cyclases appears to be adenylyl cyclase IX. AC IX is confined to the gray matter and its expression is mainly neuronal, with its highest expression located at the hippocampus. ACIX is also expressed in heart, pancreas and thyrocytes. AC I and AC IX are regulated reciprocally by intracellular free Ca2+. The inhibition of AC IX by Ca2+ is blocked by the calcineurin inhibitors FK506 and cyclosporin A.
Alternative Name:
Adenylate cyclase type 9, ATP pyrophosphate-lyase 9, Adenylate cyclase type IX, Adenylyl cyclase 9, ADCY9, KIAA0520
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200
Specificity: A Cyclase IX (P974) polyclonal antibody detects endogenous levels of A Cyclase IX protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 971-1020 of Human A Cyclase IX.
MW: ~ 161 kDa
Swis Prot.: O60503
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Classically, adenylyl cyclases respond to receptor-initiated signals, mediated by the Gs and Gi heterotrimeric G proteins. The binding of an agonist to a Gs-coupled receptor (i.e., α β-adrenergic receptor) catalyzes the exchange of GDP (bound to Gα s) for GTP, dissociation of GTP-Gα s from Gbg and Gα s-mediated activation of adenylyl cyclase. The most abundant cerebral adenylyl cyclases appears to be adenylyl cyclase IX. AC IX is confined to the gray matter and its expression is mainly neuronal, with its highest expression located at the hippocampus. ACIX is also expressed in heart, pancreas and thyrocytes. AC I and AC IX are regulated reciprocally by intracellular free Ca2+. The inhibition of AC IX by Ca2+ is blocked by the calcineurin inhibitors FK506 and cyclosporin A.
Alternative Name:
Adenylate cyclase type 9, ATP pyrophosphate-lyase 9, Adenylate cyclase type IX, Adenylyl cyclase 9, ADCY9, KIAA0520
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200
Specificity: A Cyclase IX (P974) polyclonal antibody detects endogenous levels of A Cyclase IX protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 971-1020 of Human A Cyclase IX.
MW: ~ 161 kDa
Swis Prot.: O60503
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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