A2M polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS60859
Background:
α-2-Macroglobulin (α-2M) is a homotetrameric serum protein consisting of four identical subunits that form dimers through disulfide bonds. Initially, α-2M was characterized as a pan-proteinase inhibitor thatwas able to “bait” proteinases into cleaving specific peptide sequences on α-2M. This interaction induces a conformational change in α-2M, thus enabling it to “trap” the proteinase and inhibit its further activity. Subsequently, α-2M has also been shown to function as a carrier protein and regulator of cytokines during inflammation. Circulating transforming growth factor β (TGFβ) in serum is primarily bound to α-2M,which renders TGFβ inactive. α-2M also binds to IL-6 and, thereby, increases the concentration of IL-6 near lymphocytes, hepatocytes and stem cells involved in mediating the inflammatory cascade. Mutations and deletions in the gene encoding α-2M are associated with an increased incidence of Alzheimer’s Disease (AD),which is consistent with the role of α-2M in mediating the clearance and degradation of Aβ, the major component of β-Amyloid deposits accumulated during AD.
Alternative Name:
Alpha-2-macroglobulin, Alpha-2-M, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5, A2M, CPAMD5
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200
Specificity: A2M polyclonal antibody detects endogenous levels of A2M protein.
Immunogen:
A synthetic peptide corresponding to residues in Human A2M.
MW: ~ 185 kDa
Swis Prot.: P01023
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.6.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
α-2-Macroglobulin (α-2M) is a homotetrameric serum protein consisting of four identical subunits that form dimers through disulfide bonds. Initially, α-2M was characterized as a pan-proteinase inhibitor thatwas able to “bait” proteinases into cleaving specific peptide sequences on α-2M. This interaction induces a conformational change in α-2M, thus enabling it to “trap” the proteinase and inhibit its further activity. Subsequently, α-2M has also been shown to function as a carrier protein and regulator of cytokines during inflammation. Circulating transforming growth factor β (TGFβ) in serum is primarily bound to α-2M,which renders TGFβ inactive. α-2M also binds to IL-6 and, thereby, increases the concentration of IL-6 near lymphocytes, hepatocytes and stem cells involved in mediating the inflammatory cascade. Mutations and deletions in the gene encoding α-2M are associated with an increased incidence of Alzheimer’s Disease (AD),which is consistent with the role of α-2M in mediating the clearance and degradation of Aβ, the major component of β-Amyloid deposits accumulated during AD.
Alternative Name:
Alpha-2-macroglobulin, Alpha-2-M, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5, A2M, CPAMD5
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200
Specificity: A2M polyclonal antibody detects endogenous levels of A2M protein.
Immunogen:
A synthetic peptide corresponding to residues in Human A2M.
MW: ~ 185 kDa
Swis Prot.: P01023
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.6.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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