AAK1 Antibody (N-term) Blocking Peptide
€293.00
In stock
SKU
AC-BP7861a
Background:
Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. AAK1 is a member of the SNF1 subfamily of Ser/Thr protein kinases. The protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin.
Other Names: AP2-associated protein kinase 1, Adaptor-associated kinase 1, AAK1, KIAA1048
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP7861a was selected from the N-term region of human AAK1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Type: Synthetic peptide
Primary Accession: Q2M2I8
Gene ID: 22848
Gene Name: AAK1
Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Bio References:
Henderson,D.M., Mol. Biol. Cell 18 (7), 2698-2706 (2007)Takahashi,T., Cancer Res. 66 (24), 11932-11937 (2006)Schmid,E.M., PLoS Biol. 4 (9), E262 (2006)
Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. AAK1 is a member of the SNF1 subfamily of Ser/Thr protein kinases. The protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin.
Other Names: AP2-associated protein kinase 1, Adaptor-associated kinase 1, AAK1, KIAA1048
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP7861a was selected from the N-term region of human AAK1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Type: Synthetic peptide
Primary Accession: Q2M2I8
Gene ID: 22848
Gene Name: AAK1
Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Bio References:
Henderson,D.M., Mol. Biol. Cell 18 (7), 2698-2706 (2007)Takahashi,T., Cancer Res. 66 (24), 11932-11937 (2006)Schmid,E.M., PLoS Biol. 4 (9), E262 (2006)
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