ABAT Antibody (Center) Blocking peptide
€293.00
In stock
SKU
AC-BP5316c
Background:
4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities.
Other Names: 4-aminobutyrate aminotransferase, mitochondrial, (S)-3-amino-2-methylpropionate transaminase, GABA aminotransferase, GABA-AT, Gamma-amino-N-butyrate transaminase, GABA transaminase, GABA-T, L-AIBAT, ABAT, GABAT
Type: Synthetic peptide
Primary Accession: P80404
Other Accession: NP_065737.2
Gene ID: 18
Gene Name: ABAT
Format: The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
Bio References:
Chakrabarti, B., et al. Autism Res 2(3):157-177(2009)Inada, T., et al. Pharmacogenet. Genomics 18(4):317-323(2008)Wu, C., et al. Proteomics 7(11):1775-1785(2007)
4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities.
Other Names: 4-aminobutyrate aminotransferase, mitochondrial, (S)-3-amino-2-methylpropionate transaminase, GABA aminotransferase, GABA-AT, Gamma-amino-N-butyrate transaminase, GABA transaminase, GABA-T, L-AIBAT, ABAT, GABAT
Type: Synthetic peptide
Primary Accession: P80404
Other Accession: NP_065737.2
Gene ID: 18
Gene Name: ABAT
Format: The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
Bio References:
Chakrabarti, B., et al. Autism Res 2(3):157-177(2009)Inada, T., et al. Pharmacogenet. Genomics 18(4):317-323(2008)Wu, C., et al. Proteomics 7(11):1775-1785(2007)
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