ABAT polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS7743
Background:
In the central nervous system GABA (γ-;aminobutyric acid) functions as the main inhibitory transmitter by increasing a Cl- conductance that inhibits neuronal firing. ABAT (4-aminobutyrate aminotransferase), also known as GABAT (GABA aminotransferase), L-AIBAT or (S)-3-amino-2-methylpropionate transaminase, is a 500 amino acid mitochondrial matrix protein belonging to the class-III pyridoxal-phosphate-dependent aminotransferase family, which catabolizes GABA into succinic semialdehyde. Existing as a homodimer, ABAT binds pyridoxal phosphate as a cofactor and is expressed in liver, brain, pancreas, kidney, placenta and heart. The gene encoding ABAT maps to human chromosome 16p13.2, and defects in ABAT are the cause of GABA-AT deficiency, which is characterized by hypotonia, hyperreflexia, psychomotor retardation, lethargy, EEG abnormalities and refractory seizures.
Alternative Name:
(S) 3 amino 2 methylpropionate transaminase, (S)-3-amino-2-methylpropionate transaminase, 4 aminobutyrate aminotransferase, 4 aminobutyrate aminotransferase, mitochondrial, 4-aminobutyrate aminotransferase, ABAT, FLJ17813, FLJ30272, GABA aminotransferase, GABA AT, GABA T, GABA transaminase, GABA transferase, GABA-AT, GABA-T, GABAT, GABT_HUMAN, Gamma amino N butyrate transaminase, Gamma-amino-N-butyrate transaminase, hCG1984265, L AIBAT, L-AIBAT, LAIBAT, mitochondrial, NPD009,
Application Dilution: WB: 1:500~1:2000, IHC/IF: 1:50~1:200
Specificity: ABAT polyclonal antibody detects endogenous levels of ABAT protein.
Immunogen:
Recombinant full length Human ABAT.
MW: ~ 56 kDa
Swis Prot.: P80404
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
In the central nervous system GABA (γ-;aminobutyric acid) functions as the main inhibitory transmitter by increasing a Cl- conductance that inhibits neuronal firing. ABAT (4-aminobutyrate aminotransferase), also known as GABAT (GABA aminotransferase), L-AIBAT or (S)-3-amino-2-methylpropionate transaminase, is a 500 amino acid mitochondrial matrix protein belonging to the class-III pyridoxal-phosphate-dependent aminotransferase family, which catabolizes GABA into succinic semialdehyde. Existing as a homodimer, ABAT binds pyridoxal phosphate as a cofactor and is expressed in liver, brain, pancreas, kidney, placenta and heart. The gene encoding ABAT maps to human chromosome 16p13.2, and defects in ABAT are the cause of GABA-AT deficiency, which is characterized by hypotonia, hyperreflexia, psychomotor retardation, lethargy, EEG abnormalities and refractory seizures.
Alternative Name:
(S) 3 amino 2 methylpropionate transaminase, (S)-3-amino-2-methylpropionate transaminase, 4 aminobutyrate aminotransferase, 4 aminobutyrate aminotransferase, mitochondrial, 4-aminobutyrate aminotransferase, ABAT, FLJ17813, FLJ30272, GABA aminotransferase, GABA AT, GABA T, GABA transaminase, GABA transferase, GABA-AT, GABA-T, GABAT, GABT_HUMAN, Gamma amino N butyrate transaminase, Gamma-amino-N-butyrate transaminase, hCG1984265, L AIBAT, L-AIBAT, LAIBAT, mitochondrial, NPD009,
Application Dilution: WB: 1:500~1:2000, IHC/IF: 1:50~1:200
Specificity: ABAT polyclonal antibody detects endogenous levels of ABAT protein.
Immunogen:
Recombinant full length Human ABAT.
MW: ~ 56 kDa
Swis Prot.: P80404
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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