ABCB1/p170/p-Glycoprotein/MDR Antibody (N-term) Blocking peptide
€363.00
In stock
SKU
AC-BP14142a
Background:
The membrane-associated protein encoded by this gene is amember of the superfamily of ATP-binding cassette (ABC)transporters. ABC proteins transport various molecules acrossextra- and intra-cellular membranes. ABC genes are divided intoseven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,White). This protein is a member of the MDR/TAP subfamily. Membersof the MDR/TAP subfamily are involved in multidrug resistance. Theprotein encoded by this gene is an ATP-dependent drug efflux pumpfor xenobiotic compounds with broad substrate specificity. It isresponsible for decreased drug accumulation in multidrug-resistantcells and often mediates the development of resistance toanticancer drugs. This protein also functions as a transporter inthe blood-brain barrier.
Other Names:
Multidrug resistance protein 1, ATP-binding cassette sub-family B member 1, P-glycoprotein 1, CD243, ABCB1, MDR1, PGY1
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP14142a was selected from the N-term region of ABCB1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: ABCB1 (HGNC:40)
Gene ID: 5243
Primary Accession: P08183
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
The membrane-associated protein encoded by this gene is amember of the superfamily of ATP-binding cassette (ABC)transporters. ABC proteins transport various molecules acrossextra- and intra-cellular membranes. ABC genes are divided intoseven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,White). This protein is a member of the MDR/TAP subfamily. Membersof the MDR/TAP subfamily are involved in multidrug resistance. Theprotein encoded by this gene is an ATP-dependent drug efflux pumpfor xenobiotic compounds with broad substrate specificity. It isresponsible for decreased drug accumulation in multidrug-resistantcells and often mediates the development of resistance toanticancer drugs. This protein also functions as a transporter inthe blood-brain barrier.
Other Names:
Multidrug resistance protein 1, ATP-binding cassette sub-family B member 1, P-glycoprotein 1, CD243, ABCB1, MDR1, PGY1
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP14142a was selected from the N-term region of ABCB1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: ABCB1 (HGNC:40)
Gene ID: 5243
Primary Accession: P08183
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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