ABCB6 polyclonal, anti-human, mouse, rat

Protein Family: Transporters

Pathway and Disease: Membrane Transport

Description:
ATP-binding cassette sub-family B member 6, mitochondrial (ABCB6) binds heme and porphyrins and functions in their ATP-dependent uptake into the mitochondria. ABCB6 plays a crucial role in heme synthesis. Depletion of ABCB6 by RNAi abrogates heme biosynthesis. Overexpression enhances porphyrin biosynthesis.

Alternate Names: ABCB6, ATP-binding cassette sub-family B member 6, mitochondrial, Mitochondrial ABC transporter 3, Mt-ABC transporter 3, Ubiquitously-expressed mammalian ABC half transporter, P-glycoprotein-related protein, MTABC3, PRP, UMAT

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500; IP: 1:100-1:500

Accession No.: Q9NP58

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human ABCB6.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.