ABCD3 polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS60111
Background:
The peroxisomal membrane contains several ATP-binding cassette (ABC) transporters, ABCD1-4 that are known to be present in the human peroxisome membrane. All four proteins are ABC half-transporters, which dimerize to form an active transporter. A mutation in the ABCD1 gene causes X-linked adreno-leukodystrophy (X-ALD), a peroxisomal disorder which affects lipid storage. ABCD2 in mouse is expressed at high levels in the brain and adrenal organs, which are adversely affected in X-ALD. The peroxisomal membrane comprises two quantitatively major proteins, PMP22 and ABCD3. ABCD3 is associated with irregularly shaped vesicles which may be defective peroxisomes or peroxisome precursors. ABCD1 localizes to peroxisomes. ABCB7 is a half-transporter involved in the transport of heme from the mitochondria to the cytosol.
Alternative Name:
ATP-binding cassette sub-family D member 3, 70 kDa peroxisomal membrane protein, PMP70, PMP70, PXMP1
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200
Specificity: ABCD3 polyclonal antibody detects endogenous levels of ABCD3 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human ABCD3.
MW: ~ 70-75 kDa
Swis Prot.: P28288
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The peroxisomal membrane contains several ATP-binding cassette (ABC) transporters, ABCD1-4 that are known to be present in the human peroxisome membrane. All four proteins are ABC half-transporters, which dimerize to form an active transporter. A mutation in the ABCD1 gene causes X-linked adreno-leukodystrophy (X-ALD), a peroxisomal disorder which affects lipid storage. ABCD2 in mouse is expressed at high levels in the brain and adrenal organs, which are adversely affected in X-ALD. The peroxisomal membrane comprises two quantitatively major proteins, PMP22 and ABCD3. ABCD3 is associated with irregularly shaped vesicles which may be defective peroxisomes or peroxisome precursors. ABCD1 localizes to peroxisomes. ABCB7 is a half-transporter involved in the transport of heme from the mitochondria to the cytosol.
Alternative Name:
ATP-binding cassette sub-family D member 3, 70 kDa peroxisomal membrane protein, PMP70, PMP70, PXMP1
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200
Specificity: ABCD3 polyclonal antibody detects endogenous levels of ABCD3 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human ABCD3.
MW: ~ 70-75 kDa
Swis Prot.: P28288
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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