ABCE1 polyclonal, anti-human

Protein Family: Transporters

Pathway and Disease: Signaling Molecules and Interaction

Description:
ATP-binding cassette sub-family E member 1 (ABCE1) antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. ABCE1 plays a central role in the regulation of mRNA turnover. ABCE1 antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway, an acts as a chaperone for post-translational events during HIV-1 capsid assembly.

Alternate Names: ATP-binding cassette sub-family E member 1, RNase L inhibitor, Ribonuclease 4 inhibitor, RNS4I, 2'-5'-oligoadenylate-binding protein, HuHP68, ABCE1, RLI, RNASEL1, RNASELI, RNS4I

Application Notes: E: 1:10,000-1:50,000; WB: 1:500-1:1,000

Accession No.: P61221

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human ABCE1.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.