ABCG8 polyclonal, anti-human

Protein Family: Transporters

Pathway and Disease: Lipid Metabolism, Energy Metabolism, Membrane Transport

Description:
ATP-binding cassette sub-family G member 8 (ABCG8) is a transporter that plays an indispensable role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile. Genetic variations in ABCG8 can be associated with susceptibility to gallbladder disease type 4 (GBD4). Defects in ABCG8 are also a cause of sitosterolemia (SITOST), also known as phytosterolemia or shellfish sterolemia. It is a rare autosomal recessive disorder characterized by increased intestinal absorption of all sterols including cholesterol, plant and shellfish sterols, and decreased biliary excretion of dietary sterols into bile.

Alternate Names: ATP-binding cassette sub-family G member 8, Sterolin-2, ABCG8

Application Notes: E: 1:1,1000-1:50,000; WB: 1:1,000-1:2,000

Accession No.: Q9H221

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within human ABCG8.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.