Abi-1 polyclonal, anti-human, mouse, rat
€347.00
In stock
SKU
251822
Catalog Nr.: 251822
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC, ICC
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC, ICC
Protein Family: Cytoskeleton Proteins
Pathway and Disease: Signal Transduction; Cell Growth and Death
Description:
Abelson interactor 1 (Abi-1) negatively regulates cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Abi-1 plays a role in regulation of EGF-induced Erk pathway activation. Abi-1 is involved in cytoskeletal reorganization and EGFR signaling, and together with EPS8 participates in transduction of signals from Ras to Rac. A chromosomal aberration involving Abi-1 is a cause of acute leukemias.
Alternate Names: Abl interactor 1, Abelson interactor 1, Abi-1, Spectrin SH3 domain-binding protein 1, Eps8 SH3 domain-binding protein, Eps8-binding protein, e3B1, Nap1-binding protein, Nap1BP, Abl-binding protein 4, AblBP4, ABI1, SSH3BP1
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500; ICC: 1:100-1:500
Accession No.: Q8IZP0
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human Abi-1.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 5% BSA with 0.09% sodium azide. Antibody was purified by immunogen affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Signal Transduction; Cell Growth and Death
Description:
Abelson interactor 1 (Abi-1) negatively regulates cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Abi-1 plays a role in regulation of EGF-induced Erk pathway activation. Abi-1 is involved in cytoskeletal reorganization and EGFR signaling, and together with EPS8 participates in transduction of signals from Ras to Rac. A chromosomal aberration involving Abi-1 is a cause of acute leukemias.
Alternate Names: Abl interactor 1, Abelson interactor 1, Abi-1, Spectrin SH3 domain-binding protein 1, Eps8 SH3 domain-binding protein, Eps8-binding protein, e3B1, Nap1-binding protein, Nap1BP, Abl-binding protein 4, AblBP4, ABI1, SSH3BP1
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500; ICC: 1:100-1:500
Accession No.: Q8IZP0
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human Abi-1.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 5% BSA with 0.09% sodium azide. Antibody was purified by immunogen affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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