APC (pS2054) polyclonal, anti-human, mouse, rat
€470.00
In stock
SKU
AC-AP51637
Catalog Number: AC-AP54583
Size: 100 µl
Host: Rabbit
Applications: IHC-P, IHC-F, IF
Datasheet
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Size: 100 µl
Host: Rabbit
Applications: IHC-P, IHC-F, IF
Datasheet
Request Information
Background:
Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.
Other Names:
Adenomatous polyposis coli protein, Protein APC, Deleted in polyposis 25, APC, DP25
Antigen Type: synthetic peptide
Antigen Type: APC (HGNC:583)
Gene ID: 324
Primary Accession: P25054
Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.
Other Names:
Adenomatous polyposis coli protein, Protein APC, Deleted in polyposis 25, APC, DP25
Antigen Type: synthetic peptide
Antigen Type: APC (HGNC:583)
Gene ID: 324
Primary Accession: P25054
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