ACER1 Antibody (C-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP18654b
Background:
Ceramides are synthesized during epidermal differentiationand accumulate within the interstices of the stratum corneum, wherethey represent critical components of the epidermal permeabilitybarrier. Excess cellular ceramide can trigger antimitogenic signalsand induce apoptosis, and the ceramide metabolites sphingosine andsphingosine-1-phosphate (S1P) are important bioregulatorymolecules. Ceramide hydrolysis in the nucleated cell layersregulates keratinocyte proliferation and apoptosis in response toexternal stress. Ceramide hydrolysis also occurs at the stratumcorneum, releasing free sphingoid base that functions as anendogenous antimicrobial agent. ACER1 is highly expressed inepidermis and catalyzes the hydrolysis of very long chain ceramidesto generate sphingosine (Houben et al., 2006 [PubMed 16477081]; Sunet al., 2008 [PubMed 17713573]).
Other Names:
Alkaline ceramidase 1, AlkCDase 1, Alkaline CDase 1, Acylsphingosine deacylase 3, N-acylsphingosine amidohydrolase 3, ACER1, ASAH3
Gene Name: ACER1 (HGNC:18356)
Gene ID: 125981
Primary Accession: Q8TDN7
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Ceramides are synthesized during epidermal differentiationand accumulate within the interstices of the stratum corneum, wherethey represent critical components of the epidermal permeabilitybarrier. Excess cellular ceramide can trigger antimitogenic signalsand induce apoptosis, and the ceramide metabolites sphingosine andsphingosine-1-phosphate (S1P) are important bioregulatorymolecules. Ceramide hydrolysis in the nucleated cell layersregulates keratinocyte proliferation and apoptosis in response toexternal stress. Ceramide hydrolysis also occurs at the stratumcorneum, releasing free sphingoid base that functions as anendogenous antimicrobial agent. ACER1 is highly expressed inepidermis and catalyzes the hydrolysis of very long chain ceramidesto generate sphingosine (Houben et al., 2006 [PubMed 16477081]; Sunet al., 2008 [PubMed 17713573]).
Other Names:
Alkaline ceramidase 1, AlkCDase 1, Alkaline CDase 1, Acylsphingosine deacylase 3, N-acylsphingosine amidohydrolase 3, ACER1, ASAH3
Gene Name: ACER1 (HGNC:18356)
Gene ID: 125981
Primary Accession: Q8TDN7
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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