ACER2 polyclonal, anti-human, rat
€305.00
In stock
SKU
BS60828
Background:
Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. Unsaturated long-chain ceramides are the best substrates, saturated long-chain ceramides and unsaturated very long-chain ceramides are good substrates, whereas saturated very long-chain ceramides and short-chain ceramides were poor substrates. Inhibits the maturation of protein glycosylation in the Golgi complex, including that of integrin beta-1 (ITGB1) and of LAMP1, by increasing the levels of sphingosine. Inhibits cell adhesion by reducing the level of ITGB1 in the cell surface. May have a role in cell proliferation and apoptosis that seems to depend on the balance between sphingosine and sphingosine-1-phosphate.
Alternative Name:
Alkaline ceramidase 2, AlkCDase 2, Alkaline CDase 2, haCER2, Acylsphingosine deacylase 3-like, N-acylsphingosine amidohydrolase 3-like, ACER2, ASAH3L, PP11646
Application Dilution: WB: 1:500~1:1000
Specificity: ACER2 polyclonal antibody detects endogenous levels of ACER2 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human ACER2.
MW: ~ 31 kDa
Swis Prot.: Q5QJU3
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. Unsaturated long-chain ceramides are the best substrates, saturated long-chain ceramides and unsaturated very long-chain ceramides are good substrates, whereas saturated very long-chain ceramides and short-chain ceramides were poor substrates. Inhibits the maturation of protein glycosylation in the Golgi complex, including that of integrin beta-1 (ITGB1) and of LAMP1, by increasing the levels of sphingosine. Inhibits cell adhesion by reducing the level of ITGB1 in the cell surface. May have a role in cell proliferation and apoptosis that seems to depend on the balance between sphingosine and sphingosine-1-phosphate.
Alternative Name:
Alkaline ceramidase 2, AlkCDase 2, Alkaline CDase 2, haCER2, Acylsphingosine deacylase 3-like, N-acylsphingosine amidohydrolase 3-like, ACER2, ASAH3L, PP11646
Application Dilution: WB: 1:500~1:1000
Specificity: ACER2 polyclonal antibody detects endogenous levels of ACER2 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human ACER2.
MW: ~ 31 kDa
Swis Prot.: Q5QJU3
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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